Subject: PRES
Subject: complications
Subject: cyclosporine
Subject: outcome
Subject: stem cell transplantation
Year: 2019
Type: Article
Title: Posterior Reversible Encephalopathy Syndrome (PRES) in Children Undergoing Allogeneic Stem Cell Transplantation
Author: Aleksandra Pivkova Veljanovska
Author: Stojanoski, Zlate
Author: Lazar Chadievski
Author: Irina Panovska Stavridis
Author: Sanja Trajkova
Author: Lidija Cevreska
Author: Borche Georgievski
Abstract: Posterior reversible encephalopathy syndrome (PRES) is one of the most serious complication after allogeneic stem cell transplantation in paediatric setting. It is most commonly reported as adverse event of immunosuppressive strategies during transplantation. We present a case of a 7 years old girl with myelodysplastic syndrome (MDS) treated with allogeneic stem cell transplantation (ASCT) at our department. Diagnosis of PRES was confirmed by imaging techniques during the first month after transplant and it was very likely connected with cyclosporine neurotoxicity. The aim of this article is to present our first experience in diagnosing and treating PRES in paediatric stem cell transplantation. Our experience showed that PRES is one of the reasons for higher transplant related mortality in children. Early prediction of factors contributing to PRES and closely monitoring of patient's vital signs, especially blood pressure, neurological status and vision are the main contributors for challenging the patient with another immunosuppressive agent that has less neurological toxicity. Still studies have to be initiated to confirm the influence of PRES on transplant outcome.
Publisher: Macedonian Academy of Sciences and Arts / Sciendo
Relation: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Identifier: oai:repository.ukim.mk:20.500.12188/10799
Identifier: Veljanovska AP, Stojanoski Z, Chadievski L, Stavridis IP, Trajkova S, Cevreska L, Georgievski B. Posterior Reversible Encephalopathy Syndrome (PRES) in Children Undergoing Allogeneic Stem Cell Transplantation. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2019 May 1;40(1):81-86. doi: 10.2478/prilozi-2019-0007. PMID: 31152638.
Identifier: http://hdl.handle.net/20.500.12188/10799Identifier: 10.2478/prilozi-2019-0007
