Subject: N-acetyl-β-D-glucosaminidase
Subject: symmetric dimethyl arginine
Subject: rheumatoid arthritis
Subject: immunosuppressive drugs
Year: 2013
Type: Article
Title: SYMMETRIC DIMETHYL ARGININE AND N-ACETYL-Β-DGLUCOSAMINIDASE LYSOZIMURIA OF PROXIMAL RENAL TUBULES AS A TARGET FOR NEPHROTOXICITY IN PATIENTS WITH RHEUMATOID ARTHRITIS TREATED WITH DISEASE MODIFYING ANTIRHEUMATIC DRUGS
Author: Dejan Spasovski
Author: Arif Latifi
Author: Nada Marina
Author: Jordan Calovski
Author: Irena Kafedjiska
Author: Gjorgi Božinovski
Author: Snezhana Perchinkova
Author: Maja Slaninka-Micevska
Author: Trajan Balkanov
Author: Beti Dejanova
Author: Sonja Alabakovska
Author: Svetlana Krstevska-Balkanov
Author: Goce Spasovski
Author: Vesna Janevska
Abstract: Background: The aim of this study was to determine the effect of initial therapy with some disease modifying antirheumatic drugs (DMARDs) (Methotrexate and Ketoprofen) on glomerular and tubular integrity in patients with Rheumatoid arthritis (RA). Objectives: To determine whether there is a change in clinical and laboratory indicators of renal function in course of the follow up of treatment and whether that change correlates with the dynamics of the quantity of enzymes excreted in urine and reactants of the acute phase. Materials and Methods: Using colorimetric method for determination of NAG, samples of 70 participants were examined (35 RA patients treated with Ketoprofen only, 35 RA patients treated with combined use of Methotrexate and Ketoprofen). The follow up was 5 time-intervals in the course of 24 weeks. Results: There was moderate correlation between NAG and microalbuminuria (r=0,34) in the group of patients treated with Ketoprofen only, while statistically significant correlation (r=0,21) was seen in group of patients with combined use of Methotrexate and Ketoprofen. NAG enzymuria in size, number of patients registered, and time of appearance were greater and appears earlier in the group with the combined use of Methotrexate and Ketoprofen compared with the mono-therapy with Ketoprofen. Mean urinary NAG induction was increasing with the concomitant use of Methotrexate and Ketoprofen. Conclusions: Methotrexate is more potent NAG inductor than Ketoprofen and provokes greater tubular enzymuria than Ketoprofen.
Publisher:
Relation: Journal of Nephropathology
Identifier: oai:repository.ukim.mk:20.500.12188/10366
Identifier: http://hdl.handle.net/20.500.12188/10366Identifier: 10.5812/nephropathol.8989
