Subject: Other medical sciences
Year: 2023
Type: Article
Type: PeerReviewed
Title: Zirconium-89 labeled antibodies: general considerations towards radioisotope production and labelling strategies
Author: Kolevska, Katerina
Author: Atanasova, Marija
Author: Cocevska, Maja
Author: Velickovska, Maja
Author: Janevik-Ivanovska, Emilija
Author: Angelovska, Bistra
Author: Ugrinska, Ana
Abstract: Radiopharmaceutical preparations based on zirconium-89 ( 89Zr) radioisotope in the last decade have been increasingly used in preclinical and clinical studies for visualisation by positron emission tomography (PET). There are literature data on 89Zr labelling of nanoparticles, proteins, peptides and cells, but antibody labelling is the main application of this radioisotope. As a long-lived radiometal, with a half-life of 78.4 h, zirconium-89 is suitable for visualising slow biological processes, such as antibody biodistribution (immuno-PET). 89Zr-immuno PET imaging is a promising technique for predicting the efficacy of radioimmunotherapy and antibody therapies, imaging target expression, detecting target-expressing tumours, and monitoring anti-cancer chemotherapies. According to ClinicalTrials.gov, there are more than 120 clinical studies, of which already completed studies involve more than 20 antibodies labelled with 89Zr. The most common antibodies used in these clinical trials are bevacizumab, trastuzumab, IAB2M, cetuximab, pembrolizumab, J591, panitumumab, girentuximab, pertuzumab etc. The purpose of this paper is to present the most common methods of producing zirconium-89 radioisotope and antibody labelling strategies.
Publisher:
Relation: https://eprints.ugd.edu.mk/34348/
Identifier: oai:eprints.ugd.edu.mk:34348
Identifier: https://eprints.ugd.edu.mk/34348/1/Zirconium-89%20labeled%20antibodies.pdfIdentifier: Kolevska, Katerina and Atanasova, Marija and Cocevska, Maja and Velickovska, Maja and Janevik-Ivanovska, Emilija and Angelovska, Bistra and Ugrinska, Ana (2023) Zirconium-89 labeled antibodies: general considerations towards radioisotope production and labelling strategies. Macedonian pharmaceutical bulletin, 69 (Sup.1). pp. 151-152. ISSN 1857 - 8969
