Subject: Other engineering and technologies
Subject: Other medical sciences
Subject: Other natural sciences
Year: 2000
Type: Article
Type: NonPeerReviewed
Title: Biopharmaceutical characterization of povidone-iodine liposomes
Author: Goracinova, Katerina
Author: Klisarova, Ljiljana
Author: Makraduli, Liljana
Author: Fredro-Kumbaradzi, Emilija
Author: Glavas Dodov, Marija
Author: Mladenovska, Kristina
Abstract: Different formulations of multilamellar liposomes were prepared from Soya lecithin and poly(l-vinyl-2- pyrrolidone)iodine complex by a mechanical method, vortexing the phospholipid dispersion in water. Biopharmaceu tical evaluation and antimicrobial efficacy studies were performed in order to evaluate liposome's potential for use as a sustained release depo with efficient and prolonged antimicrobial action, compared to PVP-I solution. Varying the drug/phospholipid ratio during the preparation of the liposomes, different efficacy of PVP-I encapsulation was achieved. Lower concentrations of PVP-I in the lecithin dispersion for liposome preparation resulted with higher in corporation efficacy. Dissolution test results point that total drug release (%) from the series within 24 hours was 45.08 ± 1.53, 36.15 ± 1.65, 22.54 ± 1.96, 19.98 ± 1.05 for series A, B, C and D, respectively. The in vitro microbi ological testing demonstrated good antimicrobial efficiency of PVP-I liposome dispersions against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. Also prolonged antimicrobial action, compared to PVP-I solution was noticed.
Publisher: Bulletin of the Chemists and Technologists of Macedonia
Relation: https://eprints.ugd.edu.mk/33895/
Identifier: oai:eprints.ugd.edu.mk:33895
Identifier: https://eprints.ugd.edu.mk/33895/1/XIII_2119.pdfIdentifier: Goracinova, Katerina and Klisarova, Ljiljana and Makraduli, Liljana and Fredro-Kumbaradzi, Emilija and Glavas Dodov, Marija and Mladenovska, Kristina (2000) Biopharmaceutical characterization of povidone-iodine liposomes. Bulletin of the Chemists and Technologists of Macedonia, 19 (2). pp. 133-137. ISSN 0350 - 0136
