Subject: Clinical medicine
Year: 2023
Type: Article
Type: PeerReviewed
Title: Comparison of oxidative stress levels in healthy children and children with allergic rhinitis
Author: Arnaudova Danevska, Ivana
Author: Jakjovska, Tatjana
Author: Zendelovska, Dragica
Author: Atanasovska, Emilija
Author: Dzekova-Vidimliski, Pavlina
Author: Petrushevska, Marija
Author: Boshkovska, Katerina
Author: Popova, Gorica
Author: Gjinovska Tasevska, Elena
Author: Balkanov, Trajan
Abstract: Background/aim: Allergic rhinitis (AR) is characterized by chronic inflammation of the nasal mucosa. Under the influence of exogenous factors - allergens, reactive oxygen species (ROS) are released during cellular metabolism. They induce a series of pathological changes in the mucosa. Oxidative stress is а result of an imbalance between the production of ROS and the ability to neutralize them. The aim of this study is to compare the levels of oxidative stress between healthy children and children with allergic rhinitis. Material and methods: A total number of 60 children were included (30 healthy children and 30 children with AR). The oxidative stress index was determined by using the FRAS 5 (Free Radical Analytical System) Bravo system. Demographic characteristics, medical history, children's living conditions and eating habits were obtained from the questionnaire. Anthropometric measurements and the absolute number of eosinophils in the peripheral smear were performed on each child. Results: This study showed high oxidative stress index and a significantly higher value of the absolute number of eosinophils in the peripheral smear in children with AR in comparison to healthy children (p<0.05). The group of children with AR had more atopic characteristics and was more exposed to passive smoking than healthy children. Conclusion: Compared to healthy children, children with AR have a high index of oxidative stress, despite of the very high mean value of the concentration of water-soluble antioxidants in serum (PAT test) in the group of children with AR.
Publisher: MASA
Relation: https://eprints.ugd.edu.mk/31763/
Identifier: oai:eprints.ugd.edu.mk:31763
Identifier: https://eprints.ugd.edu.mk/31763/1/3.pdfIdentifier: Arnaudova Danevska, Ivana and Jakjovska, Tatjana and Zendelovska, Dragica and Atanasovska, Emilija and Dzekova-Vidimliski, Pavlina and Petrushevska, Marija and Boshkovska, Katerina and Popova, Gorica and Gjinovska Tasevska, Elena and Balkanov, Trajan (2023) Comparison of oxidative stress levels in healthy children and children with allergic rhinitis. Contributions. Sec. of Med. Sci., 44 (1). pp. 17-26. ISSN 1857-9345
Identifier: 36987754
