Subject: Basic medicine
Subject: Biological sciences
Subject: Chemical sciences
Subject: Physical sciences
Year: 2003
Type: Article
Type: PeerReviewed
Title: Lipophilicity of Peptide Anions: An Experimental Data Set for Lipophilicity Calculations
Author: Gulaboski, Rubin
Author: Scholz, Fritz
Abstract: For the first time, the standard Gibbs energies of the transfer of peptide anions from aqueous solution to nitrobenzene were determined with the help of electrochemical measurements. These systematic studies clearly show that the lipohilicity contributions of single amino acid residues to the overall lipohilicity of a peptide anion strongly depend on the position of the amino acid in the backbone of the peptide. Therefore, additive models to calculate the overall lipophilicity of a peptide cannot provide very precise data. The present study is a plea for the experimental establishment of a data set that takes into account the individual nature of an amino acid residue and its position in a peptide.
Publisher:
Relation: https://eprints.ugd.edu.mk/165/
Identifier: oai:eprints.ugd.edu.mk:165
Identifier: https://eprints.ugd.edu.mk/165/1/__ugd.edu.mk_private_UserFiles_rubin.gulaboski_Desktop_GULABOSKI-MY%20pdf%20PUBLICATIONS_Peptidi-J%20Phys%20Chem%202003.pdfIdentifier: Gulaboski, Rubin and Scholz, Fritz (2003) Lipophilicity of Peptide Anions: An Experimental Data Set for Lipophilicity Calculations. The Journal of Physical Chemistry B, 107 (23). pp. 5650-5657. ISSN 1520-6106
Identifier: doi:10.1021/jp034387e
