Subject: Basic medicine
Subject: Biological sciences
Subject: Chemical sciences
Subject: Physical sciences
Year: 2003
Type: Article
Type: PeerReviewed
Title: Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes
Author: Bouchard, Géraldine
Author: Galland, Alexandra
Author: Carrupt, Pierre-Alain
Author: Gulaboski, Rubin
Author: Mirceski, Valentin
Author: Scholz, Fritz
Author: Girault, Hubert H.
Abstract: The anionic forms of 26 drugs and organic model compounds have been extensively explored in the n-octanol/ water system using voltammetry at three-phase electrodes. The objective of this study was to validate the ability of this electrochemical system to give reliable values of lipophilicity for organic ions, as well as to gain more information on the lipophilic behaviour of anions in the n-octanol/water system. Results were used to clarify the solvation mechanisms responsible for ion partitioning and to compare the information obtained in the two solvent systems n-octanol/water and 1,2-dichloroethane/water.
Publisher:
Relation: https://eprints.ugd.edu.mk/161/
Identifier: oai:eprints.ugd.edu.mk:161
Identifier: https://eprints.ugd.edu.mk/161/1/__ugd.edu.mk_private_UserFiles_rubin.gulaboski_Desktop_GULABOSKI-MY%20pdf%20PUBLICATIONS_Medicaments%20in%20Octanol%20PCCP%202003.pdfIdentifier: Bouchard, Géraldine and Galland, Alexandra and Carrupt, Pierre-Alain and Gulaboski, Rubin and Mirceski, Valentin and Scholz, Fritz and Girault, Hubert H. (2003) Standard partition coefficients of anionic drugs in the n-octanol/water system determined by voltammetry at three-phase electrodes. Physical Chemistry Chemical Physics, 5 (17). p. 3748. ISSN 1463-9076
Identifier: doi:10.1039/b304113a
