Subject: Basic medicine
Subject: Biological sciences
Subject: Chemical sciences
Subject: Matematics
Subject: Physical sciences
Year: 2011
Type: Article
Type: PeerReviewed
Title: Redox regulation of calcium ion channels: Chemical and physiological aspects
Author: Bogeski, Ivan
Author: Kappl, Reinhard
Author: Kummerow, Carsten
Author: Gulaboski, Rubin
Author: Hoth, Markus
Author: Niemeyer, Barbara A.
Abstract: Reactive oxygen species (ROS) are increasingly recognized as second messengers in many cellular processes. While high concentrations of oxidants damage proteins, lipids and DNA, ultimately resulting in cell death, selective and reversible oxidation of key residues in proteins is a physiological mechanism that can transiently alter their activity and function. Defects in ROS producing enzymes cause disturbed immune response and disease. Changes in the intracellular free Ca2+ concentration are key triggers for diverse cellular functions. Ca2+ homeostasis thus needs to be precisely tuned by channels, pumps, transporters and cellular buffering systems. Alterations of these key regulatory proteins by reversible or irreversible oxidation alter the physiological outcome following cell stimulation. It is therefore necessary to understand which proteins are regulated and if this regulation is relevant in a physiological- and/or pathophysiological context. Because ROS are inherently difficult to identify and to measure, we first review basic oxygen redox chemistry and methods of ROS detection with special emphasis on electron paramagnetic resonance (EPR) spectroscopy. We then focus on the present knowledge of redox regulation of Ca2+ permeable ion channels such as voltage-gated (CaV) Ca2+ channels, transient receptor potential (TRP) channels and Orai channels.
Publisher:
Relation: https://eprints.ugd.edu.mk/283/
Identifier: oai:eprints.ugd.edu.mk:283
Identifier: https://eprints.ugd.edu.mk/283/1/__ugd.edu.mk_private_UserFiles_rubin.gulaboski_Desktop_GULABOSKI-MY%20pdf%20PUBLICATIONS_Cell%20Calcium%202011_Review.pdfIdentifier: Bogeski, Ivan and Kappl, Reinhard and Kummerow, Carsten and Gulaboski, Rubin and Hoth, Markus and Niemeyer, Barbara A. (2011) Redox regulation of calcium ion channels: Chemical and physiological aspects. Cell Calcium, 50 (5). pp. 407-423. ISSN 01434160
Identifier: doi:10.1016/j.ceca.2011.07.006
